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Anti-Pepsinogen C/PGC Antibody (4C341)
还可以产品编号 TMAY-02220
Anti-Pepsinogen C/PGC Antibody (4C341) 是一种 Mouse 抗体，靶向 Pepsinogen C/PGC。Anti-Pepsinogen C/PGC Antibody (4C341) 可用于 ELISA,IHC-P。
Anti-Pepsinogen C/PGC Antibody (4C341)
Anti-Pepsinogen C/PGC Antibody (4C341)
还可以产品编号 TMAY-02220
Anti-Pepsinogen C/PGC Antibody (4C341) 是一种 Mouse 抗体，靶向 Pepsinogen C/PGC。Anti-Pepsinogen C/PGC Antibody (4C341) 可用于 ELISA,IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Pepsinogen C/PGC Antibody (4C341) is a Mouse antibody targeting Pepsinogen C/PGC. Anti-Pepsinogen C/PGC Antibody (4C341) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4C341 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human PGC in human stomach (from 3 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Pepsinogen C / PGC (rh Pepsinogen C / PGC; TMPY-01731; NP_002621.1; Met 1-Ala 388). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Pepsinogen C / PGC protein (TMPY-01731) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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