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Anti-Phospho-RELB (Ser529) Polyclonal Antibody
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产品编号 TMAC-02813
别名 RELB (p-Ser529), RELB (p-S529), p-RELB (Ser529), p-RELB (S529)
Anti-Phospho-RELB (Ser529) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Ser529)。Anti-Phospho-RELB (Ser529) Polyclonal Antibody 可用于 WB,IHC,IF。
Anti-Phospho-RELB (Ser529) Polyclonal Antibody
Anti-Phospho-RELB (Ser529) Polyclonal Antibody
还可以产品编号 TMAC-02813 别名 RELB (p-Ser529), RELB (p-S529), p-RELB (Ser529), p-RELB (S529)
Anti-Phospho-RELB (Ser529) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Ser529)。Anti-Phospho-RELB (Ser529) Polyclonal Antibody 可用于 WB,IHC,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,230 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-RELB (Ser529) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RELB (Ser529). Anti-Phospho-RELB (Ser529) Polyclonal Antibody can be used in WB,IHC,IF. |
| 别名 | RELB (p-Ser529), RELB (p-S529), p-RELB (Ser529), p-RELB (S529) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p65 (Phospho-Ser529) Antibody TMAC-02813 (left) or the same antibody preincubated with blocking peptide (right). 2. Immunofluorescence staining of methanol-fixed Hela cells using NFkB-p65 (Phospho-Ser529) Antibody TMAC-02813. 3. Western blot analysis of extracts from 293 cells untreatedor treated with TNF-α using NFκB-p65 (Phospho-Ser529)Antibody TMAC-02813. 4. Western blot analysis of extracts from MCF cells, treated with TNFa+CA or calf intestinal phosphatase (CIP), using NFκB-p65 (Phospho-Ser529) Antibody TMAC-02813. 5. Western blot analysis of extracts from Jurkat cells untreated or treated with TNF alpha or Calyculin A, using NFκB-p65 (Phospho-Ser529) Antibody TMAC-02813. |
| 应用 | |
| 推荐剂量 | IF: 1:50-200; WB: 1:500-2000; IHC: 1:100-300 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 性状 | Liquid |
| 缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 研究背景 | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | A synthesized phosphopeptide: human NFκB-p65 around the phosphorylation site of Ser529 |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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