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Anti-DARC Antibody (8R325)
还可以产品编号 TMAH-00330
Anti-DARC Antibody (8R325) 是一种抗体，靶向 DARC。Anti-DARC Antibody (8R325) 可用于 ELISA, FC。
Anti-DARC Antibody (8R325)
Anti-DARC Antibody (8R325)
还可以产品编号 TMAH-00330
Anti-DARC Antibody (8R325) 是一种抗体，靶向 DARC。Anti-DARC Antibody (8R325) 可用于 ELISA, FC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-DARC Antibody (8R325) is an antibody targeting DARC. Anti-DARC Antibody (8R325) can be used in ELISA, FC. |
| Ig Type | Rabbit IgG |
| 克隆号 | 8R325 |
| 交叉反应 | Human |
| 验证活性 | Overlay Peak curve showing 293 cells stained with TMAH-00330 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA, FC |
| 推荐剂量 | FC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human DARC |
| 抗原种属 | Human |
| 基因ID | 2532 |
| Uniprot ID | |
| 研究领域 | Cardiovascular, Immunology, Microbiology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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