规格

价格

库存

数量

10 μg

¥ 939

6-8日内发货

20 μg

¥ 1,590

5日内发货

50 μg

¥ 3,670

5日内发货

生物活性

产品描述	Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. The nuclear localization is confirmed by immunocytochemistry of neutrophils. FES has been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. FES is also involved in normal hematopoiesis. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia.
生物活性	The specific activity was determined to be 200 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
研究背景	Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. The nuclear localization is confirmed by immunocytochemistry of neutrophils. FES has been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. FES is also involved in normal hematopoiesis. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia.
种属	Human
表达系统	Baculovirus Insect Cells
标签	His, GST
蛋白编号	P07332-1
蛋白构建	A DNA sequence encoding the human FES (P07332-1) (Met 1-Arg 822) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met
蛋白纯度	> 75 % as determined by SDS-PAGE
蛋白性状	Solution
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名	FPS, FES proto-oncogene, tyrosine kinase
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.

化学信息

分子量	121 kDa (predicted); 110 kDa (reducing conditions)

储存&溶解度

运输方式

Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.

存储

It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

实际储存温度请以COA为准

FES Protein, Human, Recombinant (His & GST)

FES Protein, Human, Recombinant (His & GST)

产品介绍

引用文献

计算器

剂量转换

技术支持