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Anti-COMMD9 Antibody (6J366)
还可以产品编号 TMAY-02754
Anti-COMMD9 Antibody (6J366) 是一种 Rabbit 抗体，靶向 COMMD9。Anti-COMMD9 Antibody (6J366) 可用于 IHC-P。
Anti-COMMD9 Antibody (6J366)
Anti-COMMD9 Antibody (6J366)
还可以产品编号 TMAY-02754
Anti-COMMD9 Antibody (6J366) 是一种 Rabbit 抗体，靶向 COMMD9。Anti-COMMD9 Antibody (6J366) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-COMMD9 Antibody (6J366) is a Rabbit antibody targeting COMMD9. Anti-COMMD9 Antibody (6J366) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6J366 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human COMMD9 in human small intestine with rabbit monoclonal antibody (1:5000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human COMMD9 in human lung with rabbit monoclonal antibody (1:5000, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:2500-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human COMMD9 (rh COMMD9; TMPY-03505; Q9P000-1; Met1-Lys198). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. COMMD protein functions in the control of the transcription factor NFkappaB. NFkappaB plays a critical role in a number of homeostatic processes in multicellular organisms, including the regulation of immunity and cell survival. COMMD proteins inhibit NFkappaB mediated gene expression, and recent mechanistic studies have revealed that COMMD1 controls the ubiquitination of NFkappaB subunits, an event linked to transcriptional termination. COMMD1 binds to a multimeric ubiquitin ligase containing Elongins B/C, Cul2 and SOCS1 (ECS( SOCS1)). In this complex, COMMD1 facilitates the binding of NFkappaB subunits to the ligase, thereby promoting their ubiquitination and degradation. Additional insights gained from these studies indicate that COMMD proteins likely play a broader role in cellular homeostasis through their participation in the ubiquitination pathway. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human COMMD9 Protein (TMPY-03505) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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