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Anti-Phospho-SMC1A (Ser957) Antibody (1T770)
还可以产品编号 TMAH-00967
别名 Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC-1A, SMC1, SMC protein 1A, SB1.8, Sb1.8, Phospho-SMC1A (S957), KIAA0178, DXS423E
Anti-Phospho-SMC1A (Ser957) Antibody (1T770) 是一种抗体，靶向 Phospho-SMC1A (Ser957)。Anti-Phospho-SMC1A (Ser957) Antibody (1T770) 可用于 ELISA, WB。
Anti-Phospho-SMC1A (Ser957) Antibody (1T770)
Anti-Phospho-SMC1A (Ser957) Antibody (1T770)
还可以产品编号 TMAH-00967 别名 Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC-1A, SMC1, SMC protein 1A, SB1.8, Sb1.8, Phospho-SMC1A (S957), KIAA0178, DXS423E
Anti-Phospho-SMC1A (Ser957) Antibody (1T770) 是一种抗体，靶向 Phospho-SMC1A (Ser957)。Anti-Phospho-SMC1A (Ser957) Antibody (1T770) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Phospho-SMC1A (Ser957) Antibody (1T770) is an antibody targeting Phospho-SMC1A (Ser957). Anti-Phospho-SMC1A (Ser957) Antibody (1T770) can be used in ELISA, WB. |
| 别名 | Structural maintenance of chromosomes protein 1A, SMC1L1, SMC-1-alpha, SMC-1A, SMC1, SMC protein 1A, SB1.8, Sb1.8, Phospho-SMC1A (S957), KIAA0178, DXS423E |
| Ig Type | Rabbit IgG |
| 克隆号 | 1T770 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in 293 whole cell lysate(treated with Calyculin A or not) -All lanes Phospho-SMC1A antibody at 1.11μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 160 KDa -Observed band size: 160 KDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Chromosome. Chromosome, centromere, kinetochore. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-SMC1A (S957) |
| 抗原种属 | Human |
| 基因ID | 8243 |
| Uniprot ID | |
| 研究领域 | Cell Biology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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