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Anti-MLH1 Antibody (9P46)

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Anti-MLH1 Antibody (9P46)
产品编号 TMAC-02607
别名 MutL, E. coli, homolog of, 1, MutL protein homolog 1, MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), MutL homolog 1 colon cancer nonpolyposis type 2, MutL homolog 1 (E. coli), MutL homolog 1, MLH1_HUMAN, MLH1, MLH 1, MGC5172, HNPCC2, HNPCC 2, HNPCC, hMLH1, hMLH 1, FCC2, FCC 2, DNA mismatch repair protein Mlh1, COCA2, COCA 2

Anti-MLH1 Antibody (9P46) 是一种 Rabbit 抗体，靶向 MLH1。Anti-MLH1 Antibody (9P46) 可用于 WB,ICC/IF,IHC,IP,FCM。

Anti-MLH1 Antibody (9P46)

Anti-MLH1 Antibody (9P46)

Rating icon 还可以
Anti-MLH1 Antibody (9P46)
产品编号 TMAC-02607 别名 MutL, E. coli, homolog of, 1, MutL protein homolog 1, MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), MutL homolog 1 colon cancer nonpolyposis type 2, MutL homolog 1 (E. coli), MutL homolog 1, MLH1_HUMAN, MLH1, MLH 1, MGC5172, HNPCC2, HNPCC 2, HNPCC, hMLH1, hMLH 1, FCC2, FCC 2, DNA mismatch repair protein Mlh1, COCA2, COCA 2

Anti-MLH1 Antibody (9P46) 是一种 Rabbit 抗体，靶向 MLH1。Anti-MLH1 Antibody (9P46) 可用于 WB,ICC/IF,IHC,IP,FCM。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-MLH1 Antibody (9P46) is a Rabbit antibody targeting MLH1. Anti-MLH1 Antibody (9P46) can be used in WB,ICC/IF,IHC,IP,FCM.
别名MutL, E. coli, homolog of, 1, MutL protein homolog 1, MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), MutL homolog 1 colon cancer nonpolyposis type 2, MutL homolog 1 (E. coli), MutL homolog 1, MLH1_HUMAN, MLH1, MLH 1, MGC5172, HNPCC2, HNPCC 2, HNPCC, hMLH1, hMLH 1, FCC2, FCC 2, DNA mismatch repair protein Mlh1, COCA2, COCA 2
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of MLH1 on A431 cells lysates using anti-MLH1 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MLH1 antibody. Counter stained with hematoxylin.
3. ICC staining MLH1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. Flow cytometric analysis of Hela cells with MLH1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IHC
IP
FCM
推荐剂量
WB: 1:1000; IHC: 1:50-100; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景DNA-mismatch repair (MMR) is an essential process in maintaining genetic stability. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter methylation gene silencing. MLH1 is an integral part of the protein complex responsible for mismatch repair and is expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder tissues, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Certain cancer cell lines, including leukemia CCRF-CEM, colon HCT 116 and KM12, and ovarian cancers SK-OV-3 and IGROV-1, show complete deficiency of MLH1, while MLH1 is expressed in 60% of melanomas, 70% of noninvasive squamous cell carcinomas and 30% of invasive squamous cell carcinomas.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P40692
化学信息
分子量Theoretical: 85 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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