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顶部生物活性储存和溶解信息计算器

Anti-Nicastrin Antibody (6U336)

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产品编号 TMAY-01720

别名 nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik

Anti-Nicastrin Antibody (6U336) 是一种 Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody (6U336) 可用于 ICC/IF。

Anti-Nicastrin Antibody (6U336)

Anti-Nicastrin Antibody (6U336)

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Rating icon 还可以
产品编号 TMAY-01720 别名 nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik

Anti-Nicastrin Antibody (6U336) 是一种 Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody (6U336) 可用于 ICC/IF。

规格价格库存数量
100 μL
¥ 2,289
5日内发货
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产品介绍

生物活性
产品描述
Anti-Nicastrin Antibody (6U336) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (6U336) can be used in ICC/IF.
别名nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik
Ig Type
Rabbit IgG
克隆号
6U336
交叉反应
Human
特异性
Human Nicastrin
验证活性
Immunofluorescence staining of Human NCSTN in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human NCSTN monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.
应用ICC/IF
推荐剂量
ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human Nicastrin / NCSTN (rh Nicastrin / NCSTN; TMPY-01297; NP_056146.1; Met1-Glu669).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing pieces of evidence have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex that also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of another type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). Besides, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human Nicastrin / NCSTN protein (TMPY-01297)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

mKIAA-0253mKIAA 0253AA-727311AA 727311

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