购物车

您的购物车当前为空

(R)-ZINC-3573

Name: (R)-ZINC-3573
Brand: TargetMol
SKU: T29221
Price: 263 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.75%

货号 T29221Cas号 2089389-15-9

别名 ZINC 3573

(R)-ZINC-3573是一种有效且高选择性的MRGPRX2探针。(R)-ZINC-3573激活人肥大细胞系中的内源性MRGPRX2，诱导细胞脱粒和钙释放。

为众多的药物研发团队赋能，

让新药发现更简单！

(R)-ZINC-3573

一键复制产品信息

很棒

纯度: 99.75%

货号 T29221 别名 ZINC 3573Cas号 2089389-15-9

(R)-ZINC-3573是一种有效且高选择性的MRGPRX2探针。(R)-ZINC-3573激活人肥大细胞系中的内源性MRGPRX2，诱导细胞脱粒和钙释放。

规格	价格	库存
1 mg	¥ 263	现货
2 mg	¥ 383	现货
5 mg	¥ 581	现货
10 mg	¥ 996	现货
25 mg	¥ 1,990	现货
50 mg	¥ 2,720	现货
100 mg	¥ 3,990	现货
1 mL x 10 mM (in DMSO)	¥ 692	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.75%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

(R)-ZINC-3573 AI Summary

(R)-ZINC-3573 exhibits a broad spectrum of bioactivities, showing varying effects on cell viability across different cell types. For instance, in HEK293T cells, it can either inhibit or promote growth (Growth Rates 0.0 and 1.0, respectively). Similar mixed effects are observed in human fibroblast cells and U2OS cells, indicating cell-type-specific responses. The compound targets multiple GPCRs, including various serotonin, dopamine, adrenergic, and histamine receptors, as well as GABA, opioid receptors, Sigma receptors, and transporters such as DAT and NET. It also shows specific bioactivity towards KinomeScan targets (BTK, MAPK10, and MAPK8) and interacts with MRGPRX2 with an EC50 value of 740.0 nM in the PRESTO-Tango assay. Additionally, it affects the thermal stability of different protein domains, causing slight increases or decreases in stability (Delta TM ranging from 0.003338 to 0.6544 C increase and -0.4767 to -0.8674 C decrease). These comprehensive data suggest that (R)-ZINC-3573 has the potential for significant modulatory effects on various neurotransmitter systems and protein interactions, which may have therapeutic implications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe. (R)-ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release.
别名	ZINC 3573

化学信息

分子量	307.39
分子式	C₁₈H₂₁N₅
CAS No.	2089389-15-9
Smiles	CN(C)[C@@H]1CCN(C1)c1cc(nc2ccnn12)-c1ccccc1
密度	1.23 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.7 mg/mL (90.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.51 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2532 mL	16.2660 mL	32.5320 mL	162.6598 mL
5 mM	0.6506 mL	3.2532 mL	6.5064 mL	32.5320 mL
10 mM	0.3253 mL	1.6266 mL	3.2532 mL	16.2660 mL
20 mM	0.1627 mL	0.8133 mL	1.6266 mL	8.1330 mL
50 mM	0.0651 mL	0.3253 mL	0.6506 mL	3.2532 mL