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抗癌细胞代谢库

Name: 抗癌细胞代谢库
Brand: TargetMol
SKU: L2130

Anti-Cancer Metabolism Compound Library

很棒

产品编号 L2130

肿瘤的代谢异常已成为肿瘤学研究的热点，细胞代谢的重编程对于癌细胞维持生存和无限增殖至关重要。从德国科学家Warburg 发现肿瘤细胞存在有氧糖酵解的现象到如今对肿瘤代谢活动的各个方面(糖、脂肪、氨基酸等)的解析和复杂代谢调控网络的发现, 肿瘤代谢的研究进入了更加引人注目的高地。因此，肿瘤细胞异常的代谢通路(如葡萄糖和谷氨酰胺代谢途径)、关键代谢调控因子(如cMYC、HIF、p53)及代谢酶(如PKM、IDH、GLS)可能是肿瘤治疗的关键靶点。针对肿瘤细胞代谢改变的重要特征及其分子机制, 研制出针对特定代谢通路或特定代谢酶的高效抗肿瘤药物, 从而用于临床治疗一直是肿瘤代谢研究的目标和追求。我们根据相关文献报道筛选了多种肿瘤代谢相关的生物活性小分子组成抗癌细胞代谢库，是进行抗肿瘤药物筛选的理想工具。

TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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产品编号 L2130

抗癌细胞代谢库

规格

1 mg
30 μL x 10 mM (in DMSO)
50 μL x 10 mM (in DMSO)
100 μL x 10 mM (in DMSO)
250 μL x 10 mM (in DMSO)

询价 & 定制

产品描述

1268种癌细胞代谢相关的生物活性小分子化合物的特有集合，用于肿瘤相关的研究以及抗肿瘤药物的筛选，用于高通量、高内涵筛选；
产品经过临床验证或临床前实验，具有生物安全保障和一定的生物活性；
是肿瘤发生机理研究、抗肿瘤药物筛选的有效工具；
靶点包含16个与癌细胞糖类、脂质、氨基酸和核苷酸代谢相关靶点，如ACL、CA、FASN、GLUT、GLS、HMG-CoA、MAGL、MCTs、PDH、PDK、 PKM等等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS检测技术保证产品高纯度和高质量，减少假阳性发生概率。

包装和储存

可选用DMSO耐受的96/384孔板或2D 条形码编码管；
干粉蓝冰运输，DMSO溶液干冰运输；
排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。

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化合物库操作手册 (635 KB) Targetmol化合物库目录 (60.2 MB)

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文献引用

1.Zhou Q, Wang W, Yang F, et al. Disulfiram Suppressed Peritendinous Fibrosis Through Inhibiting Macrophage Accumulation and Its Pro-inflammatory Properties in Tendon Bone Healing. Frontiers in Bioengineering and Biotechnology. 2022, 10.2.Liang J, Yu D, Luo C, et al.Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas.Nature Communications.2023, 14(1): 3251.3.Zhang Z, Aoki H, Umezawa K, et al.Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells.Cell Death Discovery.2024, 10(1): 166.4.Lu H, Liu H, Yan R, et al.Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated intracellular pH dysregulation in HCC.Cell Reports.2024, 43(12).5.Deficiency of SDHC promotes metastasis by reprogramming fatty acid metabolism in colorectal cancer

化合物库组成

Apoptosis

PI3K

Autophagy

Dehydrogenase

mTOR

Akt

Src

Wnt/beta-catenin

STAT

AMPK

Bcr-Abl

Ras

GSK-3

CDK

Endogenous Metabolite

p53

Antibacterial

NF-κB

HIF/HIF Prolyl-Hydroxylase

Carbonic Anhydrase

DNA-PK

S6 Kinase

HIF

VEGFR

Fatty Acid Synthase

JAK

Indoleamine 2,3-Dioxygenase (IDO)

ERK

Reactive Oxygen Species

ATM/ATR

HMG-CoA Reductase

Glucokinase

FLT

c-Kit

Raf

Parasite

PDGFR

PDK

Antibiotic

Mdm2

p38 MAPK

Aurora Kinase

DNA/RNA Synthesis

transporter

FGFR

c-Myc

Ferroptosis

E1/E2/E3 Enzyme

EGFR

PKA

PARP

Rho

PI4K

HIV Protease

JNK

Mitophagy

Caspase

IDO

PKC

Isocitrate Dehydrogenase (IDH)

MAPK

MEK

PPAR

IL Receptor

IGF-1R

P450

TNF

Calcium Channel

ROCK

COX

Potassium Channel

Casein Kinase

Antifungal

Virus Protease

BCL

Chk

c-RET

FAK

Phosphatase

Stearoyl-CoA Desaturase (SCD)

MMP

Interleukin

Influenza Virus

PKM

HCV Protease

c-Met/HGFR

PDE

Mitochondrial Metabolism

Glutaminase

Sirtuin

MAGL

PTEN

c-Fms

AChR

Microtubule Associated

Topoisomerase

SIK

HSV

Somatostatin

NO Synthase

MELK

HDAC

Syk

Hck

Lipoxygenase

Epigenetic Reader Domain

TLR

SARS-CoV

Prostaglandin Receptor

Trk receptor

IκB/IKK

SGK

CAT

NPC1L1

Antioxidant

Lipase

Antifolate

Adrenergic Receptor

IAP

LDL

HBV

Nucleoside Antimetabolite/Analog

Aryl Hydrocarbon Receptor

Drug Metabolite

Glucosidase

Hexokinase

TGF-beta/Smad

P-gp

Lipid

AChE

Antiviral

Porcupine

Ephrin Receptor

Nrf2

GABA Receptor

Sodium Channel

Tyrosinase

Chloride channel

NOS

DNA Alkylator/Crosslinker

BACE

DYRK

GTPase

Transferase

Integrin

Adenosine Receptor

IFNAR

Estrogen Receptor/ERR

Serine Protease

Serine/threonin kinase

UGT

Tyrosine Kinases

CSF-1R

Gamma-secretase

BTK

ROS

GluR

cAMP

CaMK

DUB

ATP Citrate Lyase

Beta-Secretase

LRRK2

ACK

SGLT

Beta Amyloid

MLK

ALK

RSV

Reverse Transcriptase

CRISPR/Cas9

PLK

Cannabinoid Receptor

Anti-infection

NADPH-oxidase

TAM Receptor

DHFR

Estrogen/progestogen Receptor

Arginase

RAAS

Tie-2

Glutathione Peroxidase

ATPase

Proton pump

Dopamine Receptor

YAP

PERK

OCT

TRP/TRPV Channel

MAO

Glucocorticoid Receptor

iGluR

Myosin

RIP kinase

NMDAR

MRP

Pim

cell cycle arrest

Cysteine Protease

FXR

Guanylate cyclase

DNA Alkylation

CXCR

BCRP

Glutathione reductase

HSP

Hedgehog/Smoothened

FAAH

Epoxide Hydrolase

Androgen Receptor

OAT

Histone Acetyltransferase

Pyroptosis

Methionine Adenosyltransferase (MAT)

KLF

5-HT Receptor

DAPK

cholecystokinin

p97

AhR

CFTR

hCE

GPX

Retinoid Receptor

Aquaporin

Hydroxylase

ROS Kinase

PD-1/PD-L1

Kinesin

S1P Receptor

HER

化合物库信息

Empty	2361289-44-1	938440-64-3	504-88-1	1616413-96-7	1992052-49-9	1313363-54-0	1246535-95-4	1628428-01-2	5142-23-4	728033-96-3	Empty
Empty	CHIKV-IN-2	KU-0063794	3-Nitropropanoic acid	UCB9608	SI-2 hydrochloride	NVP-CGM097	Desmethyl-VS-5584	PKR-IN-2	3-Methyladenine	OSI-930	Empty
Empty	529-44-2	140674-76-6	24418-86-8	1627710-50-2	548472-68-0	6035-49-0	405168-58-3	345630-40-2	350678-63-6	1680196-54-6	Empty
Empty	Myricetin	AG957	SKI V	LJH685	Nutlin-3	Dimethylfraxetin	CHIR-124	SF1670	p53-Mdm2 inhibitor 4	FzM1	Empty
Empty	21018-84-8	784210-88-4	1092351-67-1	220036-08-8	881202-45-5	702674-56-4	1233339-22-4	6080-58-6	1422253-38-0	321695-57-2	Empty
Empty	AMAROGENTIN	RGB-286638 free base	Torkinib	NU6027	Serdemetan	BX-912	AZ20	Citric acid trilithium salt tetrahydrate	PRI-724	L002	Empty
Empty	372196-67-3	901751-47-1	284028-89-3	1135237-88-5	79498-31-0	1485-00-3	133-67-5	1473404-51-1	1369452-53-8	376640-41-4	Empty
Empty	PIK-75	iCRT3	XAV-939	ADH-1 trifluoroacetate	Glaucocalyxin A	MNS	Trichlormethiazide	Hck-IN-1	KL-11743	BVT 2733	Empty
Empty	863127-77-9	477575-56-7	1360540-82-4	20137-37-5	1402837-78-8	100-51-6	834-28-6	2009343-14-8	3934-84-7	1421783-64-3	Empty
Empty	Dasatinib monohydrate	PHA-665752	Wnt pathway activator 2	Rotundic acid	Navoximod	Benzyl alcohol	Phenformin hydrochloride	PHD-1-IN-1	3-O-Methylgallic acid	Olverembatinib dimesylate	Empty
Empty	882290-02-0	73069-13-3	241127-58-2	1469337-95-8	1922098-69-8	28808-62-0	1616690-16-4	1148126-03-7	854001-07-3	60477-38-5	Empty
Empty	SC99	Atractylenolide I	Adaphostin	K-Ras(G12C) inhibitor 12	CCG-222740	Fraxinellone	Desidustat	DHODH-IN-8	Dasatinib hydrochloride	Pifithrin-α, p-Nitro, Cyclic	Empty
Empty	1927857-61-1	691868-88-9	520-28-5	88495-63-0	172889-26-8	1672666-82-8	1313881-70-7	517-89-5	1421366-99-5	123134-61-2	Empty
Empty	PQR530	RO8191	Tectochrysin	Artesunate	PP1	HIF-2α-IN-2	Miransertib	Shikonin	ElteN378	TMBIM6 antagonist-1	Empty
Empty	18274-81-2	345627-80-7	340267-36-9	1062159-35-6	59-05-2	2150-47-2	593960-11-3	53716-50-0	1228013-15-7	1962178-27-3	Empty
Empty	Desmethylanethol trithione	SNS-032	CAY10404	WAY-600	Methotrexate	Methyl 2,4-dihydroxybenzoate	PIK-93	Oxfendazole	CC-115	PF-04802367	Empty

Keywords

AntiCancer Metabolism Compound Library Anti Cancer Metabolism Compound Library

抗癌细胞代谢库

产品编号 L2130

规格

产品描述

包装和储存

使用TargetMol产品 发表顶级期刊文献

SCI 文献

文件下载

化合物库定制

文献引用

化合物库组成

化合物库信息

Keywords

使用TargetMol产品
发表顶级期刊文献