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Anti-MERS-CoV Spike/S1 Antibody (8F43)
还可以产品编号 TMAY-02863
Anti-MERS-CoV Spike/S1 Antibody (8F43) 是一种 Mouse 抗体，靶向 MERS-CoV Spike/S1。Anti-MERS-CoV Spike/S1 Antibody (8F43) 可用于 ELISA。
Anti-MERS-CoV Spike/S1 Antibody (8F43)
Anti-MERS-CoV Spike/S1 Antibody (8F43)
还可以产品编号 TMAY-02863
Anti-MERS-CoV Spike/S1 Antibody (8F43) 是一种 Mouse 抗体，靶向 MERS-CoV Spike/S1。Anti-MERS-CoV Spike/S1 Antibody (8F43) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-MERS-CoV Spike/S1 Antibody (8F43) is a Mouse antibody targeting MERS-CoV Spike/S1. Anti-MERS-CoV Spike/S1 Antibody (8F43) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 8F43 |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 ( TMPY-03574; AFS88936.1; Met1-Glu725). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2 (angiotensin-converting enzyme 2), DPP4 (dipeptidyl peptidase-4), APN (aminopeptidase N), CEACAM (carcinoembryonic antigen-related cell adhesion molecule), Sia (sialic acid), O-ac Sia (O-acetylated sialic acid). The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant MERS-CoV (NCoV / Novel coronavirus) Spike Protein S1 Protein (TMPY-03574) |
| 抗原种属 | MERS-CoV |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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