Name: SEMA4B Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPK-01034
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 298

3日内发货

10 μg

¥ 472

3日内发货

20 μg

¥ 768

3日内发货

50 μg

¥ 1,490

3日内发货

100 μg

¥ 2,510

现货

200 μg

¥ 4,530

5日内发货

500 μg

¥ 10,000

5日内发货

生物活性

产品描述	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q62179
蛋白构建	Leu31-Glu703
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	SemC, Semaphorin-C, Semaphorin-4B, SEMAC, SEMA4B, MGC131831, KIAA1745
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	75.7 kDa (predicted). Due to glycosylation, the protein migrates to 78-83 kDa based on Tris-Bis PAGE result.

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

SEMA4B Protein, Mouse, Recombinant (His)

SEMA4B Protein, Mouse, Recombinant (His)

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