store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin A 具有抗菌、抗疟活性以及溶血活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 560 | 35日内发货 | ||
5 mg | ¥ 1,750 | 35日内发货 | ||
10 mg | ¥ 3,220 | 35日内发货 | ||
25 mg | ¥ 6,660 | 35日内发货 |
产品描述 | Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities. |
靶点活性 | ACHN:0.783, Caki-1 cells:0.228 μM, 786-O:0.430 μM, SN12C:0.104 μM, A498:0.420 μM |
体外活性 |
Gramicidin A (0.1 nM-10 μM; 72 h) reduces the viability of RCC cell lines and affects cell viability comparable to Monensin.[2] Gramicidin A (1 and 10 μM, 48 or 72 h) induces nonapoptotic cell death in RCC cells.[2] Gramicidin A (0-10 μM, 24 h) depletes cellular energy and induces metabolic dysfunction in RCC cells.[2] Gramicidin A (0-1 μM, 24-72 h) reduces HIF-1α and HIF-2α protein expression and reduces HIF transcriptional activity and target gene expression (24 h).[3] |
体内活性 |
Gramicidin A (0.11 mg/kg; intratumoral injection; 2 weeks; 14 days) inhibits the growth of RCC tumor xenografts, the average tumor mass was reduced by approximately 40% without significant toxicity.[2] Gramicidin A (0.22 mg/kg; intratumoral injection; 3 weeks; 26 days) inhibits the growth and angiogenesis of VHL-expressing RCC tumor xenografts.[3] |
分子量 | 1882.29 |
分子式 | C99H140N20O17 |
CAS No. | 11029-61-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
H2O: Slightly soluble
Ethanol: Soluble
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gramicidin A 11029-61-1 Angiogenesis Chromatin/Epigenetic Microbiology/Virology Antibacterial HIF Parasite Inhibitor inhibitor inhibit