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Anti-Mucin-4/MUC4 Antibody (8K130) 是一种 Rabbit 抗体,靶向 Mucin-4/MUC4。Anti-Mucin-4/MUC4 Antibody (8K130) 可用于 WB,IHC,FCM。
Anti-Mucin-4/MUC4 Antibody (8K130) 是一种 Rabbit 抗体,靶向 Mucin-4/MUC4。Anti-Mucin-4/MUC4 Antibody (8K130) 可用于 WB,IHC,FCM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,485 | 5日内发货 | |
100 μL | ¥ 2,480 | 5日内发货 |
产品描述 | Anti-Mucin-4/MUC4 Antibody (8K130) is a Rabbit antibody targeting Mucin-4/MUC4. Anti-Mucin-4/MUC4 Antibody (8K130) can be used in WB,IHC,FCM. |
别名 | Testis mucin, Pancreatic adenocarcinoma mucin, Mucin-4, MUC-4, Muc4, Ascites sialoglycoprotein (ASGP) |
Ig Type | IgG |
交叉反应 | Human,Rat |
应用 | |
推荐剂量 | WB: 1:500; IHC: 1:50-200; FCM: 1:50-100 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). Mucin 4 protein consists of Mucin 4α, a large amino mucin type subunit, and Mucin 4β, a transmembrane subunit containing three EGF-like domains. The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of Mucin 4 results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of Mucin 4 in pancreatic carcinoma by all-trans-retinoic acid is mediated through the retinoic acid receptor-α signaling pathway. TGFβ2 serves as an interim mediator of this regulated expression. Alternative splicing in the 3'-end of the Mucin 4 gene generates at least 12 splice variants, which are characterized as two distinct types, a secreted type and a membrane-associated type. Mucin 4 protein acts as a heterodimeric bifunctional cell-surface glycoprotein and forms thick mucous effusion in the diseased middle ear. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein |
Uniprot ID |
分子量 | Theoretical: 120 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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