Name: Nidanilimab
Brand: TargetMol
SKU: T76873
Price: 2480 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,480

现货

5 mg

¥ 5,860

现货

10 mg

¥ 7,890

现货

25 mg

¥ 11,700

现货

50 mg

¥ 15,800

现货

生物活性

产品描述	Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destroy tumor cells. Nidanilimab can be used to study solid cancers such as non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).
靶点活性	MC38 colon cancer cells (mouse):1 nM(EC50)
体外活性	Nidanilimab (CAN04; 20 µg/mL) 在小鼠MC38结肠癌细胞中表现出具有糖基工程增强属性的抗体依赖性细胞介导的细胞毒性（ADCC），EC50值小于1 nM[2]。同样，Nidanilimab (20 µg/mL) 通过阻断小鼠MC38结肠癌细胞中的IL1α和IL1β信号通路，分别具有3.9 nM和4.1 nM的IC50值[2]。
体内活性	在裸C57Bl/6小鼠中，Nidanilimab（CAN04；10 mg/kg；腹腔注射）增强了两种常用的铂基化疗药物，顺铂和卡铂配合吉西他滨的疗效[1]。
别名	尼达利单抗, Nadunolimab, CAN04
反应种属	Human
验证活性	Immobilized Human IL-1RAP/IL-1R3, Fc tag at 2 μg/mL (30 μL/well) can bind Nidanilimab with the EC50 of 19.97 ng/mL.
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
内毒素	< 1 EU/mg as determined by the LAL method

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Nidanilimab