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Anti-DcR2/TRAIL R4 Antibody (2I306)
还可以产品编号 TMAY-00784
Anti-DcR2/TRAIL R4 Antibody (2I306) 是一种 Mouse 抗体，靶向 DcR2/TRAIL R4。Anti-DcR2/TRAIL R4 Antibody (2I306) 可用于 ELISA,IHC-P。
Anti-DcR2/TRAIL R4 Antibody (2I306)
Anti-DcR2/TRAIL R4 Antibody (2I306)
还可以产品编号 TMAY-00784
Anti-DcR2/TRAIL R4 Antibody (2I306) 是一种 Mouse 抗体，靶向 DcR2/TRAIL R4。Anti-DcR2/TRAIL R4 Antibody (2I306) 可用于 ELISA,IHC-P。
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抗原信息
| 产品描述 | Anti-DcR2/TRAIL R4 Antibody (2I306) is a Mouse antibody targeting DcR2/TRAIL R4. Anti-DcR2/TRAIL R4 Antibody (2I306) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2I306 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human TNFRSF10D in human liver with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human TNFRSF10D in human kidney with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TRAIL R4 / CD264 / TNFRSF10D (rh TRAIL R4 / CD264 / TNFRSF10D; TMPY-01381; NP_003831.2; Met 1-His 211). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human TRAIL R4 / CD264 / TNFRSF10D Protein (TMPY-01381) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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