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顶部生物活性储存和溶解信息计算器

Anti-Phospho-PTEN (Ser380) Antibody (6H501)

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Anti-Phospho-PTEN (Ser380) Antibody (6H501)
产品编号 TMAH-00949
别名 TEP1, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del

Anti-Phospho-PTEN (Ser380) Antibody (6H501) 是一种抗体，靶向 Phospho-PTEN (Ser380)。Anti-Phospho-PTEN (Ser380) Antibody (6H501) 可用于 ELISA, WB。

Anti-Phospho-PTEN (Ser380) Antibody (6H501)

Anti-Phospho-PTEN (Ser380) Antibody (6H501)

Rating icon 还可以
Anti-Phospho-PTEN (Ser380) Antibody (6H501)
产品编号 TMAH-00949 别名 TEP1, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del

Anti-Phospho-PTEN (Ser380) Antibody (6H501) 是一种抗体，靶向 Phospho-PTEN (Ser380)。Anti-Phospho-PTEN (Ser380) Antibody (6H501) 可用于 ELISA, WB。

规格价格库存数量
50 μL
¥ 1,315
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100 μL
¥ 2,195
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PTEN (Ser380) Antibody (6H501) is an antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6H501) can be used in ELISA, WB.
别名TEP1, PTEN1, PTEN (p-Ser380), PTEN (p-S380), p-PTEN (Ser380), p-PTEN (S380), Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Ig Type
Rabbit IgG
克隆号
6H501
交叉反应
Human
验证活性
Western Blot
-Positive WB detected in HepG2 whole cell lysate
-All lanes Phospho-PTEN antibody at 1.9μg/ml
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 54 KDa
-Observed band size: 54 KDa
应用
ELISA
WB
推荐剂量
WB:1:500-1:5000.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Nucleus. Nucleus, PML body.; [Isoform alpha]: Secreted. Note=May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.
组织特异性Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Phospho-PTEN (S380)
抗原种属
Human
基因名称
PTEN
基因ID
5728
Uniprot ID
P60484
研究领域
Cell Biology
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

PTEN (pSer380)PTEN (pS380)PTEN (phospho-Ser380)PTEN (phospho-S380)pPTEN (Ser380)pPTEN (S380)

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