Anti-RET Antibody (1L221)

Name: Anti-RET Antibody (1L221)
Brand: TargetMol
SKU: TMAY-02197
Rating: 4.5 (1 reviews)

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产品编号 TMAY-02197

Anti-RET Antibody (1L221) 是一种 Rabbit 抗体，靶向 RET。Anti-RET Antibody (1L221) 可用于 ELISA。

Anti-RET Antibody (1L221)

还可以

产品编号 TMAY-02197

Anti-RET Antibody (1L221) 是一种 Rabbit 抗体，靶向 RET。Anti-RET Antibody (1L221) 可用于 ELISA。

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产品描述	Anti-RET Antibody (1L221) is a Rabbit antibody targeting RET. Anti-RET Antibody (1L221) can be used in ELISA.
Ig Type	Monoclonal Rabbit IgG
克隆号	1L221
交叉反应	Human
应用	ELISA
推荐剂量	ELISA: 1:5000-1:10000
抗体种类	Monoclonal
宿主来源	Rabbit
构建方式	This antibody was obtained from a rabbit immunized with purified, recombinant Human RET (rh RET; TMPY-02270; P07949-1; Met1-Arg635).
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily, tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life; promotes the formation of Peyer's patch-like structures; modulates cell adhesion via its cleavage; involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand, triggering apoptosis. RET acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size; triggers the differentiation of rapidly adapting (RA) mechanoreceptors; mediated several diseases such as neuroendocrine cancers. Defects in RET may cause colorectal cancer, hirschsprung disease type 1, medullary thyroid carcinoma, multiple neoplasia type 2B, susceptibility to pheochromocytoma, multiple neoplasia type 2A, thyroid papillary carcinoma and congenital central hypoventilation syndrome.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human RET protein (TMPY-02270)
抗原种属	Human
研究领域	Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.