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Anti-IL6ST Monoclonal Antibody-Biotin

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Anti-IL6ST Monoclonal Antibody-Biotin
产品编号 TMAZ-0043B
别名 Oncostatin-M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, CDw130

Anti-IL6ST Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF.

Anti-IL6ST Monoclonal Antibody-Biotin

Anti-IL6ST Monoclonal Antibody-Biotin

Rating icon 还可以
Anti-IL6ST Monoclonal Antibody-Biotin
产品编号 TMAZ-0043B 别名 Oncostatin-M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, CDw130

Anti-IL6ST Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF.

规格价格库存数量
25 μg
¥ 842
7日内发货
50 μg
¥ 1,010
7日内发货
100 μg
¥ 1,414
7日内发货
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实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-IL6ST Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF.
别名Oncostatin-M receptor subunit alpha, Membrane glycoprotein 130, Interleukin-6 signal transducer, Interleukin-6 receptor subunit beta, CDw130
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of IL6ST overexpressed 293F cells with TMAZ-0043B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL6ST protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Signal-transducing molecule (PubMed: 2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed: 19915009, PubMed: 2261637, PubMed: 23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed: 19915009, PubMed: 23294003, PubMed: 25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed: 19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)|Binds to the soluble IL6: sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed: 11121117, PubMed: 21990364, PubMed: 30279168). Also blocks IL11 cluster signaling through IL11R (PubMed: 30279168)
偶联与修饰
偶联
Biotin
其他可选修饰符
Unconjugated
可提供抗体种类
2
抗原信息
免疫原
IL6ST
抗原种属
Human
基因ID
Uniprot ID
研究领域
Immunology Research, Drug Target
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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