Name: Substance P TFA
Brand: TargetMol
SKU: TP2155
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 mg

¥ 5,898

5日内发货

生物活性

产品描述	Substance P TFA (Neurokinin P TFA) is a neuropeptide that functions as both a neurotransmitter and neuromodulator in the central nervous system, specifically targeting the neurokinin 1 receptor (NK1-receptor, NK1R).
体外活性	The neuropeptide substance P (SP) is mediated by the NK1-R desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R have internalized into the same clathrin immunoreactive vesicles and then sorted into different compartments. SP is intact at the cell surface and in early endosomes but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP induces the internalization of the NK1-R both in transfected epithelial cells [1].
别名	Neurokinin P TFA

化学信息

分子量	1461.67
分子式	C₆₅H₉₉F₃N₁₈O₁₅S
CAS No.	148470-19-3
Smiles	OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
密度	no data available
Sequence	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Short	RPKPQQFFGLM

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Substance P TFA