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顶部生物活性储存和溶解信息计算器

Anti-PRDM1 Antibody (4L235)

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Anti-PRDM1 Antibody (4L235)
产品编号 TMAC-03412
别名 PRDM1_HUMAN, Prdm1, PRDM 1, PRDI-binding factor 1, PRDI-BF1, PRDI binding factor 1, PRDI BF1, PR domain-containing protein 1, PR domain zinc finger protein 1, PR domain containing protein 1, PR domain containing 1 with ZNF domain isoform 2, PR domain containing 1 with ZNF domain, PR Domain Containing 1, Positive regulatory domain I-binding factor 1, Positive Regulatory Domain I Binding Factor 1, BLIMP-1, BLIMP1, Beta-interferon gene positive regulatory domain I-binding factor, Beta interferon gene positive regulatory domain I binding factor, B Lymphocyte Induced Maturation Protein 1

Anti-PRDM1 Antibody (4L235) 是一种 Mouse 抗体，靶向 PRDM1。Anti-PRDM1 Antibody (4L235) 可用于 WB,ICC,FCM。

Anti-PRDM1 Antibody (4L235)

Anti-PRDM1 Antibody (4L235)

Rating icon 还可以
Anti-PRDM1 Antibody (4L235)
产品编号 TMAC-03412 别名 PRDM1_HUMAN, Prdm1, PRDM 1, PRDI-binding factor 1, PRDI-BF1, PRDI binding factor 1, PRDI BF1, PR domain-containing protein 1, PR domain zinc finger protein 1, PR domain containing protein 1, PR domain containing 1 with ZNF domain isoform 2, PR domain containing 1 with ZNF domain, PR Domain Containing 1, Positive regulatory domain I-binding factor 1, Positive Regulatory Domain I Binding Factor 1, BLIMP-1, BLIMP1, Beta-interferon gene positive regulatory domain I-binding factor, Beta interferon gene positive regulatory domain I binding factor, B Lymphocyte Induced Maturation Protein 1

Anti-PRDM1 Antibody (4L235) 是一种 Mouse 抗体，靶向 PRDM1。Anti-PRDM1 Antibody (4L235) 可用于 WB,ICC,FCM。

规格价格库存数量
50 μL
¥ 1,990
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100 μL
¥ 2,990
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产品介绍

生物活性
产品描述
Anti-PRDM1 Antibody (4L235) is a Mouse antibody targeting PRDM1. Anti-PRDM1 Antibody (4L235) can be used in WB,ICC,FCM.
别名PRDM1_HUMAN, Prdm1, PRDM 1, PRDI-binding factor 1, PRDI-BF1, PRDI binding factor 1, PRDI BF1, PR domain-containing protein 1, PR domain zinc finger protein 1, PR domain containing protein 1, PR domain containing 1 with ZNF domain isoform 2, PR domain containing 1 with ZNF domain, PR Domain Containing 1, Positive regulatory domain I-binding factor 1, Positive Regulatory Domain I Binding Factor 1, BLIMP-1, BLIMP1, Beta-interferon gene positive regulatory domain I-binding factor, Beta interferon gene positive regulatory domain I binding factor, B Lymphocyte Induced Maturation Protein 1
交叉反应
Human
验证活性
1. Western blot analysis of PRDM1 on human PRDM1 recombinant protein using anti-PRDM1 antibody at 1/1,000 dilution.
2. Western blot analysis of PRDM1 on HEK293 (1) and PRDM1-hIgGFc transfected HEK293 (2) cell lysate using anti-PRDM1 antibody at 1/1,000 dilution.
3. ICC staining PRDM1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. Flow cytometric analysis of Raji cells with PRDM1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
应用
WB
ICC
FCM
推荐剂量
WB: 1:500-2000; ICC: 1:200-1000; FCM: 1:100-200
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
O75626
化学信息
分子量Theoretical: 92 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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