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Anti-MDM2 Antibody (6Z692)
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产品编号 TMAC-02509
别名 RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein
Anti-MDM2 Antibody (6Z692) 是一种 Mouse 抗体，靶向 MDM2。Anti-MDM2 Antibody (6Z692) 可用于 WB,IP,IF,IHC-P。
Anti-MDM2 Antibody (6Z692)
Anti-MDM2 Antibody (6Z692)
还可以产品编号 TMAC-02509 别名 RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein
Anti-MDM2 Antibody (6Z692) 是一种 Mouse 抗体，靶向 MDM2。Anti-MDM2 Antibody (6Z692) 可用于 WB,IP,IF,IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,980 | 5日内发货 | |
| 100 μL | ¥ 2,995 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-MDM2 Antibody (6Z692) is a Mouse antibody targeting MDM2. Anti-MDM2 Antibody (6Z692) can be used in WB,IP,IF,IHC-P. |
| 别名 | RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Mdm2, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of MDM2 expression in U-2OS (A), A-673 (B) and RAW 264.7 (C) whole cell lysates. |
| 应用 | |
| 推荐剂量 | WB: 1:100-1000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression represents at least one mechanism by which p53 function can be abrogated during tumorigenesis. |
| 偶联 | Unconjugated |
| 免疫原 | Amino acids 154-167 of MDM2 of human origin |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 90 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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