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- 2508种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选；
- 靶点含KRas, MEK, ERK, RAF, PI3K, HER2, EGFR, JAK/STAT, IGF-1R, VEGF, TGFβ等；
- 部分化合物已上市或已进入临床期；
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
抗胰腺癌化合物库
Anti-Pancreatic Cancer Compound Library
很棒随着医学技术的进步，大部分癌症的生存率都在提高，例如乳腺癌，结直肠癌等肿瘤，近几十年来，生存率得到了大幅度的提升。但是，有一个例外，那就是胰腺癌，胰腺癌是一种发病隐匿，进展迅速，治疗效果和预后极差的消化道恶性肿瘤。胰腺癌的生存率一直停滞不前，胰腺癌的五年生存率只有5%至10%，绝大部分患者在诊断胰腺癌半年内死亡，由于生存率低，死亡率高，胰腺癌称为癌中之王。
为了满足胰腺癌研究客户的需求，TargeMol 收集了 2508 种与胰腺癌相关的化合物，作用于 KRas, MEK, ERK, RAF, PI3K, HER2, EGFR, JAK/STAT, IGF-1R, VEGF, TGFβ等胰腺癌相关靶点，助力胰腺癌治疗药物的开发。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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化合物库相关信息
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抗胰腺癌化合物库规格
- 1 mg
- 10 μL x 10 mM (in DMSO)
- 20 μL x 10 mM (in DMSO)
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品特点
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
- 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求，采用其他溶剂或浓度包装，具体以实际产品信息为准。
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化合物库组成
Apoptosis
Autophagy
NF-κB
PI3K
EGFR
CDK
COX
VEGFR
Ras
PPAR
Akt
Wnt/beta-catenin
mTOR
JAK
ERK
HDAC
STAT
PARP
Src
Endogenous Metabolite
p38 MAPK
GSK-3
AMPK
Antibacterial
FGFR
Raf
c-Met/HGFR
ROS
PDGFR
MDM-2/p53
FLT
Caspase
TGF-beta/Smad
Parasite
Kras
p53
JNK
c-Kit
MEK
Reactive Oxygen Species
MMP
TNF
Potassium Channel
IGF-1R
DNA/RNA Synthesis
S6 Kinase
Bcr-Abl
HIF/HIF Prolyl-Hydroxylase
Tyrosine Kinases
DNA-PK
Interleukin
MAPK
ATM/ATR
Ferroptosis
Bcl-2 Family
Cytochromes P450
Aurora Kinase
ALK
HER
HIV Protease
NO Synthase
Influenza Virus
Antibiotic
Mdm2
Gamma-secretase
Mitophagy
IL Receptor
c-RET
STING
PD-1/PD-L1
PDK
Antifungal
Hedgehog/Smoothened
HIF
Pim
PKC
E1/E2/E3 Enzyme
Dehydrogenase
Beta Amyloid
Virus Protease
FAK
Calcium Channel
Nrf2
BTK
Lipoxygenase
PKA
Prostaglandin Receptor
Casein Kinase
IκB/IKK
PI4K
Topoisomerase
c-Fms
Trk receptor
Epigenetic Reader Domain
PDE
Chk
NOS
Phosphatase
Rho
TAM Receptor
Tyrosinase
HSV
Adrenergic Receptor
Anti-infection
TLR
GABA Receptor
Sodium Channel
ROCK
Mitochondrial Metabolism
HCV Protease
PTEN
P-gp
Sirtuin
Drug Metabolite
PGE Synthase
Microtubule Associated
DYRK
c-Myc
5-HT Receptor
PLK
Syk
Tie-2
SIK
Smo
HSP
Antioxidant
PERK
Antifection
Adenosine Receptor
Ephrin Receptor
Integrin
AChR
Aryl Hydrocarbon Receptor
MLK
IAP
RIP kinase
GPCR
Histone Acetyltransferase
MELK
TRP/TRPV Channel
CaMK
SGK
Serine Protease
Proteasome
CSF-1R
Glucosidase
SARS-CoV
Cannabinoid Receptor
ATPase
Estrogen/progestogen Receptor
PYK2
Survivin
IRAK
ROS Kinase
IFNAR
Antiviral
transporter
NOD-like Receptor (NLR)
Estrogen Receptor/ERR
Serine/threonin kinase
Carbonic Anhydrase
glycosidase
Histone Methyltransferase
GTPase
NOD
Transferase
Hck
Reductase
Histamine Receptor
Cholecystokinin Receptor
Chloride channel
Proton pump
DNA Alkylator/Crosslinker
Opioid Receptor
Retinoid Receptor
HBV
CCR
Cholinesterase (ChE)
Dopamine Receptor
MRP
UGT
Fatty Acid Synthase
Androgen Receptor
Discoidin Domain Receptor (DDR)
cAMP
BACE
Glucocorticoid Receptor
DNA Methyltransferase
NMDAR
Angiotensin-converting Enzyme (ACE)
DUB
MNK
DNA Alkylation
Acyltransferase
Decarboxylase
Phospholipase
Glutathione Peroxidase
Leukotriene Receptor
LDL
OXPHOS
LRRK2
Free radical scavengers
FKBP
Histone Demethylase
Nucleoside Antimetabolite/Analog
ATP Citrate Lyase
Porcupine
Hippo pathway
Adenylate cyclase
Aminopeptidase
DAPK
Kinesin
Progesterone Receptor
PAK
Reverse Transcriptase
Aromatase
Gap Junction Protein
ADC Cytotoxin
NADPH
RANKL/RANK
Lipid
Cell Cycle Arrest
Glucokinase
Immunology/Inflammation related
RSV
S1P Receptor
RAAS
Beta-Secretase
FXR
Prolyl Endopeptidase (PREP)
Pyroptosis
NADPH-oxidase
iGluR
ABC Transporter
Monoamine Transporter
FAAH
GluR
CFTR
LPL Receptor
MIF
Glutaminase
PAD
Thrombopoietin Receptor
BCRP
ASK
Methionine Adenosyltransferase (MAT)
p97
Y Box Binding Protein 1
Arginase
Na+/Ca2+ Exchanger
gp120/CD4
ASCT
Liver X Receptor
AIM2
PAI-1
YAP
OCT
Na-K-Cl cotransporter
ACK1
hCE
LPA Receptor
BMI-1
Thrombin
Monoamine Oxidase
MicroRNA
ROR
Amino Acids and Derivatives
PAFR
Haspin Kinase
Hexokinase
DPP-4
Melanin-concentrating Hormone Receptor (MCHR)
NPC1L1
DHFR
TOPK
Myosin
FLAP
Thioredoxin
Adenosine Deaminase
RAR/RXR
MyD88
Cysteine Protease
IRE1
FABP
Guanylate cyclase
Epoxide Hydrolase
Cadherin
PKM
CD38
LTR
VDA
NR4A
DNA
CRISPR/Cas9
Hydroxylase
Sigma receptor
Keywords
肿瘤抑制胰腺肿瘤胰腺导管腺癌胰腺癌药物重定位老药新用抗肿瘤抗胰腺癌化合物库抗癌药物发现抗癌研究抗癌先导化合物抗癌筛选库高通量筛选表型筛选靶点筛选Tumor suppressionTarget-based screeningPhenotypic screeningPDACPancreatic tumorPancreatic ductal adenocarcinoma (PDAC)Pancreatic cancerHigh-throughput screeningDrug repurposingDrug rediscoveryCompound libraryCancer screening libraryCancer researchCancer lead compoundsCancer drug discoveryAntitumorAntiPancreatic Cancer Compound LibraryAnti Pancreatic Cancer Compound Library
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