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HGFR/c-Met Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-01895

别名: c-Met, AI838057, MET proto-oncogene, receptor tyrosine kinase, HGFR, Par4, HGF

HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.

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HGFR/c-Met Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,170		5日内发货
1 mg	￥ 20,800		5日内发货

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized human HGF at 2 μg/ml (100 μl/well) can bind mouse HGFR with a linear range of 1.28-32ng/ml.
产品描述	HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	A4FUV6
别名	c-Met, AI838057, MET proto-oncogene, receptor tyrosine kinase, HGFR, Par4, HGF
蛋白构建	The Mouse MET (NP_032617.2) extracellular domain (Met 1-Asn 929) was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 92 % as determined by SDS-PAGE
分子量	128 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. McGill GG,et al.(2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73. 2. Garcia S,et al.(2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35. 3. Socoteanu MP,et al.(2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4. 4. Kong DS,et al.(2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.

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Keywords

HGFR/c-Met Protein, Mouse, Recombinant (hFc) c-Met AI 838057 AI838057 AI-838057 MET proto-oncogene, receptor tyrosine kinase HGFR Par4 HGF recombinant recombinant-proteins proteins protein

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