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CD20 Protein, Human, Recombinant (His & Flag)

CD20 Protein, Human, Recombinant (His & Flag)

产品编号 TMPJ-00185
别名: CD20, Membrane-spanning 4-domains subfamily A member 1, B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Bp35, MS4A1, B-lymphocyte antigen CD20

CD20 Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with C-6xHis-Flag tag. The predicted molecular weight is 34-40 kDa and the accession number is P11836.

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CD20 Protein, Human, Recombinant (His & Flag)
规格 价格/CNY 货期 数量
10 μg ¥ 2,360 5日内发货
50 μg ¥ 7,110 5日内发货
500 μg ¥ 44,500 5日内发货
1 mg ¥ 67,300 5日内发货
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产品目录号及名称: CD20 Protein, Human, Recombinant (His & Flag) (TMPJ-00185)
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生物活性
技术参数
产品性质
生物活性 Loaded Anti-Human CD20 mAb-Fc on AHC Biosensor, can bind Human CD20-His-Flag with an affinity constant of 1.3 pM as determined in BLI assay. (Regularly tested)
产品描述 CD20 Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with C-6xHis-Flag tag. The predicted molecular weight is 34-40 kDa and the accession number is P11836.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis-Flag
蛋白编号 P11836
别名 CD20, Membrane-spanning 4-domains subfamily A member 1, B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Bp35, MS4A1, B-lymphocyte antigen CD20
氨基酸序列 Met1-Pro297
蛋白构建 Met1-Pro297
蛋白纯度 Greater than 80% as determined by reducing SDS-PAGE. (QC verified)
分子量 34-40 kDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Supplied as a 0.2 μm filtered solution of 50 mM HEPES-Na, 150 mM NaCl, 0.02%DDM, 0.004%CHS, 5%Glycerol, pH7.5.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 CD20 is a 33-37 kDa non-glycosylated protein expressed on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. CD20 protein consists of four hydrophobic transmembrane domains, one intracellular and two extracellular domains (large and small loops) with both N- and C- termini residing within the cytosol. CD20 is also known to be physically coupled to major histocompatibility complex class II (MHCII), CD40 molecule, BCR, and the C-terminal src kinase-binding protein (CBP) that interacts with Src kinases such as LYN, FYN, and LCK. CD20 deficiency resulted in a reduced number of circulating memory B cells, reduced isotype switching of Ig, and decreased IgG antibody levels. In agreement with this observation, challenging the patient’s primary B cells in vitro using T-dependent and Tindependent antigens led to the normal proliferation and secretion of IgM but reduced production of IgG.

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Keywords

CD20 Protein, Human, Recombinant (His & Flag) CD20 Membrane-spanning 4-domains subfamily A member 1 CD-20 B-lymphocyte surface antigen B1 Leukocyte surface antigen Leu-16 Bp35 CD 20 MS4A1 B-lymphocyte antigen CD20 recombinant recombinant-proteins proteins protein

 

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