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Anti-S1PR1 Antibody (4A625)
还可以产品编号 TMAH-01066
别名 Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor 1, S1PR 1, S1P1, S1P receptor Edg-1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, CD antigen CD363
Anti-S1PR1 Antibody (4A625) 是一种抗体，靶向 S1PR1。Anti-S1PR1 Antibody (4A625) 可用于 ELISA, WB。
Anti-S1PR1 Antibody (4A625)
Anti-S1PR1 Antibody (4A625)
还可以产品编号 TMAH-01066 别名 Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor 1, S1PR 1, S1P1, S1P receptor Edg-1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, CD antigen CD363
Anti-S1PR1 Antibody (4A625) 是一种抗体，靶向 S1PR1。Anti-S1PR1 Antibody (4A625) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-S1PR1 Antibody (4A625) is an antibody targeting S1PR1. Anti-S1PR1 Antibody (4A625) can be used in ELISA, WB. |
| 别名 | Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1-phosphate receptor 1, S1PR 1, S1P1, S1P receptor Edg-1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, EDG1, CHEDG1, CD antigen CD363 |
| Ig Type | Rabbit IgG |
| 克隆号 | 4A625 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: SH-SY5Y whole cell lysate, PC3 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, U251 whole cell lysate -All lanes: EDG1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 43 kDa -Observed band size: 43 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human EDG1 |
| 抗原种属 | Human |
| 基因ID | 1901 |
| Uniprot ID | |
| 研究领域 | Cancer, Cardiovascular, Cell biology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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