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TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)

产品编号 TMPJ-00174
别名: T-cell immunoglobulin mucin receptor 3, Hepatitis A virus cellular receptor 2 homolog, HAVcr-2, Tim3, T-cell membrane protein 3, Timd3, T-cell immunoglobulin and mucin domain-containing protein 3

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0.

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TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)
规格 价格/CNY 货期 数量
10 μg ¥ 740 5日内发货
50 μg ¥ 1,970 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) (TMPJ-00174)
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产品描述 TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0.
种属 Mouse
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 Q8VIM0
别名 T-cell immunoglobulin mucin receptor 3, Hepatitis A virus cellular receptor 2 homolog, HAVcr-2, Tim3, T-cell membrane protein 3, Timd3, T-cell immunoglobulin and mucin domain-containing protein 3
氨基酸序列 Arg20-Ala193
蛋白构建 Arg20-Ala193
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 38-55 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

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Keywords

TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) T-cell immunoglobulin mucin receptor 3 Hepatitis A virus cellular receptor 2 homolog HAVcr-2 Tim3 T-cell membrane protein 3 Timd3 T-cell immunoglobulin and mucin domain-containing protein 3 recombinant recombinant-proteins proteins protein

 

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