Influenza A H18N11 (A/flat-faced bat/Peru/033/2010) HA1

Influenza A H18N11 (A/flat-faced bat/Peru/033/2010) Hemagglutinin/HA1 Protein (His)

产品编号 TMPY-00107

Influenza A H18N11 (A/flat-faced bat/Peru/033/2010) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.8 kDa and the accession number is U5N1D3.

规格	价格	库存	数量
100 μg	¥ 4,460	5日内发货

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常见问题解答

问化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别？盐形式和游离态有什么区别？

答盐和非盐形式化合物的活性分子是一样的，在生物实验中起到的效果也一致，活性和使用方法都是一样的。只是由于呈盐不同，物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。

问如何选择某个靶点的特异性或总的抑制剂？特异性和非特异性的区别是什么？

答抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂，对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。一般评价一个抑制剂的抑制效率主要看 IC50 值，IC50 值越低，说明抑制剂效率越高。建议您根据以上几个特征进行综合选择，也可联系技术帮您推荐相关抑制剂。

产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	Influenza A H18N11 (A/flat-faced bat/Peru/033/2010) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.8 kDa and the accession number is U5N1D3.
种属	H18N11
表达系统	HEK293 Cells
标签	C-His
蛋白编号	U5N1D3
别名	Harvey rat sarcoma viral oncogene homolog
蛋白构建	A DNA sequence encoding the Influenza A virus (A/flat-faced bat/Peru/033/2010 (H18N11)) hemagglutinin (AGX84934.1) (Met1-Arg339), termed as HA1, was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Asp 15
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	37.8 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.