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TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
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很棒纯度: 98.6%
货号 TMPJ-00249
别名 转化生长因子, Transforming Growth Factor β-1, Transforming Growth Factor Beta-1, TGF-β-1, TGF-β1, TGF-Beta-1, TGFB1, TGFB, Latency-Associated Peptide, LAP
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
其他形式的 “TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated”:
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
一键复制产品信息 很棒纯度: 98.6%
货号 TMPJ-00249 别名 转化生长因子, Transforming Growth Factor β-1, Transforming Growth Factor Beta-1, TGF-β-1, TGF-β1, TGF-Beta-1, TGFB1, TGFB, Latency-Associated Peptide, LAP
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 1,970 | 现货 | |
| 10 μg | ¥ 3,390 | 现货 | |
| 20 μg | ¥ 5,730 | 现货 | |
| 50 μg | ¥ 9,870 | 5日内发货 | |
| 100 μg | ¥ 15,800 | 5日内发货 |
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产品介绍
生物活性
化学信息
储存&溶解度
| 产品描述 | Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease. |
| 生物活性 | 1. Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 137.37pg/ml. (Regularly tested)
2. Immobilized Biotinylated Human TGF-beta 1-Avi at 2μg/ml (100 μl/well) can bind Human TGFBR2-Fc. The ED50 of Human TGFBR2-Fc is 9.47ng/ml. (Regularly tested)   |
| 研究背景 | Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | N-Avi |
| 蛋白编号 | P01137 |
| 氨基酸序列 | Ala279-Ser390 |
| 蛋白构建 | Ala279-Ser390 |
| 蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified)  |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Glycine-HCl, 150 mM NaCl, pH2.5. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | 转化生长因子, Transforming Growth Factor β-1, Transforming Growth Factor Beta-1, TGF-β-1, TGF-β1, TGF-Beta-1, TGFB1, TGFB, Latency-Associated Peptide, LAP |
| 内毒素 | < 10 EU/mg of the protein as determined by the LAL method. |
| 分子量 | 12-18 KDa (reducing condition) |
| 颜色 | White |
| 物理性状 | Lyophilized powder |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| 存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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