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Anti-WWP2 Antibody (7A673)
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产品编号 TMAY-02489
别名 WWp2-like, WW domain containing E3 ubiquitin protein ligase 2, AIP2
Anti-WWP2 Antibody (7A673) 是一种 Mouse 抗体，靶向 WWP2。Anti-WWP2 Antibody (7A673) 可用于 ELISA。
Anti-WWP2 Antibody (7A673)
Anti-WWP2 Antibody (7A673)
还可以产品编号 TMAY-02489 别名 WWp2-like, WW domain containing E3 ubiquitin protein ligase 2, AIP2
Anti-WWP2 Antibody (7A673) 是一种 Mouse 抗体，靶向 WWP2。Anti-WWP2 Antibody (7A673) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-WWP2 Antibody (7A673) is a Mouse antibody targeting WWP2. Anti-WWP2 Antibody (7A673) can be used in ELISA. |
| 别名 | WWp2-like, WW domain containing E3 ubiquitin protein ligase 2, AIP2 |
| Ig Type | Mouse IgG2a |
| 克隆号 | 7A673 |
| 交叉反应 | Human |
| 应用 | |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human WWP2 (rh WWP2; TMPY-02950; O00308; Met1-Glu870). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. WWP2 ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. It also ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. WWP2 ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human WWP2 protein (TMPY-02950) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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