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Anti-L1CAM Antibody-PE (5I245)
还可以产品编号 TMAY-00333P
Anti-L1CAM Antibody-PE (5I245) 是一种 PE-conjugated Mouse 抗体，靶向 L1CAM。Anti-L1CAM Antibody-PE (5I245) 可用于 FCM。
Anti-L1CAM Antibody-PE (5I245)
Anti-L1CAM Antibody-PE (5I245)
还可以产品编号 TMAY-00333P
Anti-L1CAM Antibody-PE (5I245) 是一种 PE-conjugated Mouse 抗体，靶向 L1CAM。Anti-L1CAM Antibody-PE (5I245) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-L1CAM Antibody-PE (5I245) is a PE-conjugated Mouse antibody targeting L1CAM. Anti-L1CAM Antibody-PE (5I245) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 5I245 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD171 expression in HeLa cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD171 / N-CAML1 / L1CAM (rh CD171 / N-CAML1 / L1CAM; TMPY-01431; NP_000416.1; Met1-Glu1120) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CD171 / N-CAML1 / L1CAM protein (TMPY-01431) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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