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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-FANCD2 Antibody (4N89)

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货号 TMAB-05896

Anti-FANCD2 Antibody (4N89) 是一种 Rabbit 抗体，靶向 FANCD2。Anti-FANCD2 Antibody (4N89) 可用于 WB,ICC/IF,IP。

Anti-FANCD2 Antibody (4N89)

Anti-FANCD2 Antibody (4N89)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05896

Anti-FANCD2 Antibody (4N89) 是一种 Rabbit 抗体，靶向 FANCD2。Anti-FANCD2 Antibody (4N89) 可用于 WB,ICC/IF,IP。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-FANCD2 Antibody (4N89) is a Rabbit antibody targeting FANCD2. Anti-FANCD2 Antibody (4N89) can be used in WB,ICC/IF,IP.
Ig Type
IgG
克隆号
4N89
反应种属
Human
应用WBICC/IFIP
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50-200; IP: 1:20-50
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Note=Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks.
组织特异性Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress.
抗原信息
免疫原
A synthesized peptide: human FANCD2
抗原种属
Human
基因名称
FANCD2
基因ID
2177
蛋白名称
Fanconi anemia group D2 protein
Uniprot ID
Q9BXW9
功能
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
化学信息
分子量Theoretical: 164 kDa. Actual: 166 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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