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Anti-HGFR/c-Met Antibody (8M497)
还可以产品编号 TMAH-00748
别名 RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9
Anti-HGFR/c-Met Antibody (8M497) 是一种抗体，靶向 HGFR/c-Met。Anti-HGFR/c-Met Antibody (8M497) 可用于 ELISA, IHC。
Anti-HGFR/c-Met Antibody (8M497)
Anti-HGFR/c-Met Antibody (8M497)
还可以产品编号 TMAH-00748 别名 RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9
Anti-HGFR/c-Met Antibody (8M497) 是一种抗体，靶向 HGFR/c-Met。Anti-HGFR/c-Met Antibody (8M497) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-HGFR/c-Met Antibody (8M497) is an antibody targeting HGFR/c-Met. Anti-HGFR/c-Met Antibody (8M497) can be used in ELISA, IHC. |
| 别名 | RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9 |
| Ig Type | Rabbit IgG |
| 克隆号 | 8M497 |
| 交叉反应 | Human |
| 验证活性 | 1. IHC image of TMAH-00748 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 2. IHC image of TMAH-00748 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis. (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human c-Met |
| 抗原种属 | Human |
| 基因ID | 4233 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Cancer, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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