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Anti-C-Kit Antibody-PE (1R766)
还可以产品编号 TMAY-02194P
Anti-C-Kit Antibody-PE (1R766) 是一种 PE-conjugated Rabbit 抗体，靶向 C-Kit。Anti-C-Kit Antibody-PE (1R766) 可用于 FCM。
Anti-C-Kit Antibody-PE (1R766)
Anti-C-Kit Antibody-PE (1R766)
还可以产品编号 TMAY-02194P
Anti-C-Kit Antibody-PE (1R766) 是一种 PE-conjugated Rabbit 抗体，靶向 C-Kit。Anti-C-Kit Antibody-PE (1R766) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-C-Kit Antibody-PE (1R766) is a PE-conjugated Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody-PE (1R766) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1R766 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of human KIT (CD117) expression on TF-1 cells. TF-1 cells were stained with PE-conjugated anti-Human KIT (CD117). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human c-Kit / CD117 (rh c-Kit / CD117; TMPY-01935; P10721-2; Met1-Thr516) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family, and CSF-1/PDGF receptor subfamily. C-Kit has tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumor in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumors and in distinguishing seminomas from embryonal carcinomas. Mutations in the c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human c-Kit / CD117 protein (TMPY-01935) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Cardiac Stem Cell Markers, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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