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Anti-MGMT Antibody (6G140)
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产品编号 TMAC-02579
别名 O-6-methylguanine-DNA-alkyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase
Anti-MGMT Antibody (6G140) 是一种 Rabbit 抗体，靶向 MGMT。Anti-MGMT Antibody (6G140) 可用于 WB,IHC。
Anti-MGMT Antibody (6G140)
Anti-MGMT Antibody (6G140)
还可以产品编号 TMAC-02579 别名 O-6-methylguanine-DNA-alkyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase
Anti-MGMT Antibody (6G140) 是一种 Rabbit 抗体，靶向 MGMT。Anti-MGMT Antibody (6G140) 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-MGMT Antibody (6G140) is a Rabbit antibody targeting MGMT. Anti-MGMT Antibody (6G140) can be used in WB,IHC. |
| 别名 | O-6-methylguanine-DNA-alkyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of MGMT on different lysates using anti-MGMT antibody at 1/1,000 dilution. Positive control: Lane 1: MCF-7, Lane 2: Hela. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MGMT antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-MGMT antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 22 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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