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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RELB (Thr505) Polyclonal Antibody

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Anti-Phospho-RELB (Thr505) Polyclonal Antibody
产品编号 TMAC-02817
别名 RELB (p-Thr505), RELB (p-T505), p-RELB (Thr505), p-RELB (T505)

Anti-Phospho-RELB (Thr505) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Thr505)。Anti-Phospho-RELB (Thr505) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-RELB (Thr505) Polyclonal Antibody

Anti-Phospho-RELB (Thr505) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-RELB (Thr505) Polyclonal Antibody
产品编号 TMAC-02817 别名 RELB (p-Thr505), RELB (p-T505), p-RELB (Thr505), p-RELB (T505)

Anti-Phospho-RELB (Thr505) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RELB (Thr505)。Anti-Phospho-RELB (Thr505) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RELB (Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RELB (Thr505). Anti-Phospho-RELB (Thr505) Polyclonal Antibody can be used in WB,IHC.
别名RELB (p-Thr505), RELB (p-T505), p-RELB (Thr505), p-RELB (T505)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from HL60 cells untreated or treated with TNF-a using NFkB-p65 (Phospho-Thr505) Antibody TMAC-02817.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p65 (Phospho-Thr505) Antibody TMAC-02817 (left) or the same antibody preincubated with blocking peptide (right).
应用
WB
IHC
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of threonine 505 (L-V-T(p)-G-A) derived from Human NFkB-p65
抗原种属
human
Uniprot ID
Q04206
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

RELB (pThr505)RELB (pT505)RELB (phospho-Thr505)RELB (phospho-T505)pRELB (Thr505)pRELB (T505)

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