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Anti-PCSK9 Antibody (5J838)
还可以产品编号 TMAH-00860
别名 proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, LDLCQ1, HCHOLA3, FH3
Anti-PCSK9 Antibody (5J838) 是一种抗体，靶向 PCSK9。Anti-PCSK9 Antibody (5J838) 可用于 ELISA, IHC。
Anti-PCSK9 Antibody (5J838)
Anti-PCSK9 Antibody (5J838)
还可以产品编号 TMAH-00860 别名 proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, LDLCQ1, HCHOLA3, FH3
Anti-PCSK9 Antibody (5J838) 是一种抗体，靶向 PCSK9。Anti-PCSK9 Antibody (5J838) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PCSK9 Antibody (5J838) is an antibody targeting PCSK9. Anti-PCSK9 Antibody (5J838) can be used in ELISA, IHC. |
| 别名 | proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, LDLCQ1, HCHOLA3, FH3 |
| Ig Type | mIgG2a |
| 克隆号 | 5J838 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00860 diluted at 1:200 and staining in paraffin-embedded human liver performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human PCSK9 Protein |
| 抗原种属 | Human |
| 基因ID | 255738 |
| Uniprot ID | |
| 研究领域 | Cancer, Cardiovascular, Cell biology, Metabolism, Signal transduction, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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