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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-PCSK9 Antibody (5J838)

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货号 TMAH-00860

别名 proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, LDLCQ1, HCHOLA3, FH3

Anti-PCSK9 Antibody (5J838) 是一种抗体，靶向 PCSK9。Anti-PCSK9 Antibody (5J838) 可用于 ELISA,IHC。

Anti-PCSK9 Antibody (5J838)

Anti-PCSK9 Antibody (5J838)

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货号 TMAH-00860 别名 proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, LDLCQ1, HCHOLA3, FH3

Anti-PCSK9 Antibody (5J838) 是一种抗体，靶向 PCSK9。Anti-PCSK9 Antibody (5J838) 可用于 ELISA,IHC。

规格价格库存数量
50 μL
¥ 1,300
5日内发货
100 μL
¥ 2,185
5日内发货
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产品介绍

生物活性
产品描述
Anti-PCSK9 Antibody (5J838) is an antibody targeting PCSK9. Anti-PCSK9 Antibody (5J838) can be used in ELISA,IHC.
别名proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, LDLCQ1, HCHOLA3, FH3
Ig Type
mIgG2a
克隆号
5J838
反应种属
Human
验证活性
IHC image of TMAH-00860 diluted at 1:200 and staining in paraffin-embedded human liver performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
应用ELISAIHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
组织特异性Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human PCSK9 Protein
抗原种属
Human
基因名称
PCSK9
基因ID
255738
Uniprot ID
Q8NBP7
研究领域
Cancer, Cardiovascular, Cell biology, Metabolism, Signal transduction, Stem cells
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

PC-9PC 9NARC 1LDLCQ-1LDLCQ 1HCHOLA-3HCHOLA 3FH-3FH 3
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