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CDCP1 Protein, Human, Recombinant (mFc)

CDCP1 Protein, Human, Recombinant (mFc)

产品编号 TMPY-03149
别名: TRASK, SIMA135, CD318, CUB domain containing protein 1

CDCP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.4 kDa and the accession number is Q9H5V8-3.

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CDCP1 Protein, Human, Recombinant (mFc)
规格 价格/CNY 货期 数量
50 μg ¥ 3,820 5日内发货
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产品目录号及名称: CDCP1 Protein, Human, Recombinant (mFc) (TMPY-03149)
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生物活性 Testing in progress
产品描述 CDCP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.4 kDa and the accession number is Q9H5V8-3.
种属 Human
表达系统 HEK293 Cells
标签 C-mFc
蛋白编号 Q9H5V8-3
别名 TRASK, SIMA135, CD318, CUB domain containing protein 1
蛋白构建 The Human CDCP1 (Q9H5V8-3) (Met1-Glu343) was fused with Fc region of Mouse IgG1 at the C-terminus.
蛋白纯度 ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量 61.4 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets.

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Keywords

CDCP1 Protein, Human, Recombinant (mFc) TRASK SIMA 135 CD 318 SIMA135 CD318 CUB domain containing protein 1 SIMA-135 CD-318 recombinant recombinant-proteins proteins protein

 

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