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Anti-ACCN1 Polyclonal Antibody

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货号 TMAB-02192

别名 Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN

Anti-ACCN1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ACCN1。Anti-ACCN1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-ACCN1 Polyclonal Antibody

Anti-ACCN1 Polyclonal Antibody

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货号 TMAB-02192 别名 Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN

Anti-ACCN1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ACCN1。Anti-ACCN1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-ACCN1 Polyclonal Antibody is a Rabbit antibody targeting ACCN1. Anti-ACCN1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
别名Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Cow,Horse,Rabbit)
验证活性
1. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min;
Incubation: Anti-ACCN1 Polyclonal Antibody, Unconjugated (TMAB-02192) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining
2. Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human U251 cell lysates
Lane 3: Human U-2 OS cell lysates
Lane 4: Human Jurkat cell lysates
Primary: Anti-ACCN1 (TMAB-02192) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kDa
Observed band size: 60,63 kDa
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
组织特异性Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Degenerin/epithelial sodium channel (DEG/ENaC) superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and C-termini, 2 two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated ASIC3, SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ACCN1
抗原种属
Human
基因名称
ASIC2
基因ID
40
蛋白名称
Acid-sensing ion channel 2
Uniprot ID
Q16515
功能
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
化学信息
分子量Theoretical: 56 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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