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VCAM-1 Protein, Human, Recombinant (hFc)

VCAM-1 Protein, Human, Recombinant (hFc)

产品编号 TMPY-00947
别名: INCAM-100, CD106, VCAM-1, vascular cell adhesion molecule 1

VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.

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VCAM-1 Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 2,520 现货
200 μg ¥ 4,470 5日内发货
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产品目录号及名称: VCAM-1 Protein, Human, Recombinant (hFc) (TMPY-00947)
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生物活性
技术参数
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参考文献
生物活性 Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When cells are added to VCAM1 coated plates (10 μg/mL, 100 μL/well) approximately > 70% cells will adhere after 1 hour of incubation at 37℃.
产品描述 VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 P19320-1
别名 INCAM-100, CD106, VCAM-1, vascular cell adhesion molecule 1
蛋白构建 The extracellular domain (Met 1-Pro 697) of Human VCAM1 (NP_001069.1) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度 ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

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分子量 100.8 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

VCAM-1 Protein, Human, Recombinant (hFc) INCAM-100 INCAM 100 CD 106 CD106 VCAM-1 CD-106 VCAM1 VCAM 1 INCAM100 vascular cell adhesion molecule 1 recombinant recombinant-proteins proteins protein

 

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