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Anti-HGFR/c-Met Antibody (4Y373)
还可以产品编号 TMAY-01067
Anti-HGFR/c-Met Antibody (4Y373) 是一种 Mouse 抗体，靶向 HGFR/c-Met。Anti-HGFR/c-Met Antibody (4Y373) 可用于 WB。
Anti-HGFR/c-Met Antibody (4Y373)
Anti-HGFR/c-Met Antibody (4Y373)
还可以产品编号 TMAY-01067
Anti-HGFR/c-Met Antibody (4Y373) 是一种 Mouse 抗体，靶向 HGFR/c-Met。Anti-HGFR/c-Met Antibody (4Y373) 可用于 WB。
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| 产品描述 | Anti-HGFR/c-Met Antibody (4Y373) is a Mouse antibody targeting HGFR/c-Met. Anti-HGFR/c-Met Antibody (4Y373) can be used in WB. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4Y373 |
| 交叉反应 | Human |
| 验证活性 | 1. Anti-HGFR mouse monoclonal antibody at 1:500 dilution. -Lane A: Hela Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:156 kDa. 2. Anti-c-MET mouse monoclonal antibody at 1:500 dilution. -Lane A: Hela Whole Cell Lysate. -Lane B: c-MET konckout Hela Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:156 kDa(Validation Experiment) |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human c-MET (rh c-MET; TMPY-01296; NP_000236.2; Met1-Thr932). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human c-MET Protein (TMPY-01296) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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