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Anti-L1CAM Antibody-APC (5I245)

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Anti-L1CAM Antibody-APC (5I245)
产品编号 TMAY-00333A
别名 SPG1, S10, NCAM-L1, N-CAM-L1, N-CAML1, MIC5, MASA, L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1

Anti-L1CAM Antibody-APC (5I245) 是一种 APC-conjugated Mouse 抗体,靶向 L1CAM。Anti-L1CAM Antibody-APC (5I245) 可用于 FCM。

Anti-L1CAM Antibody-APC (5I245)

Anti-L1CAM Antibody-APC (5I245)

Rating icon 还可以
Anti-L1CAM Antibody-APC (5I245)
产品编号 TMAY-00333A 别名 SPG1, S10, NCAM-L1, N-CAM-L1, N-CAML1, MIC5, MASA, L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1

Anti-L1CAM Antibody-APC (5I245) 是一种 APC-conjugated Mouse 抗体,靶向 L1CAM。Anti-L1CAM Antibody-APC (5I245) 可用于 FCM。

规格价格库存数量
25 T
¥ 690
5日内发货
100 T
¥ 895
5日内发货
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实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-L1CAM Antibody-APC (5I245) is a APC-conjugated Mouse antibody targeting L1CAM. Anti-L1CAM Antibody-APC (5I245) can be used in FCM.
别名SPG1, S10, NCAM-L1, N-CAM-L1, N-CAML1, MIC5, MASA, L1 cell adhesion molecule, HSAS1, HSAS, CD171, CAML1
Ig Type
Mouse IgG2a
克隆号
5I245
交叉反应
Human
验证活性
Flow cytometric analysis of Human L1CAM expression on Hela cells. Cells were stained with APC-conjugated anti-Human L1CAM. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
推荐剂量
5 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD171 / N-CAML1 / L1CAM (rh CD171 / N-CAML1 / L1CAM; TMPY-01431; NP_000416.1; Met1-Glu1120) and conjugated with APC under optimum conditions, the unreacted APC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.09% sodium azide
研究背景L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.
偶联与修饰
偶联
APC
其他可选修饰符
Unconjugated/PE
可提供抗体种类
3
抗原信息
免疫原
Recombinant Protein: Human CD171 / N-CAML1 / L1CAM protein (TMPY-01431)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
运输方式Shipping with blue ice.

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