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顶部生物活性储存和溶解信息计算器

Anti-C-Kit Antibody-PE (7P530)

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产品编号 TMAY-02192P

别名 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, PBT, C-Kit, CD117

Anti-C-Kit Antibody-PE (7P530) 是一种 PE-conjugated Mouse 抗体，靶向 C-Kit。Anti-C-Kit Antibody-PE (7P530) 可用于 FCM。

Anti-C-Kit Antibody-PE (7P530)

Anti-C-Kit Antibody-PE (7P530)

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Rating icon 还可以
产品编号 TMAY-02192P 别名 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, PBT, C-Kit, CD117

Anti-C-Kit Antibody-PE (7P530) 是一种 PE-conjugated Mouse 抗体，靶向 C-Kit。Anti-C-Kit Antibody-PE (7P530) 可用于 FCM。

规格价格库存数量
25 T
¥ 695
5日内发货
100 T
¥ 1,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-C-Kit Antibody-PE (7P530) is a PE-conjugated Mouse antibody targeting C-Kit. Anti-C-Kit Antibody-PE (7P530) can be used in FCM.
别名v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, PBT, C-Kit, CD117
Ig Type
Mouse IgG1
克隆号
7P530
交叉反应
Human
特异性
Human c-Kit
验证活性
Flow cytometric analysis of Human KIT(CD117) expression on TF-1 cells. Cells were stained with PE-conjugated anti-Human KIT(CD117). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用FCM
推荐剂量
5 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human c-Kit (rh c-Kit; TMPY-01935; P10721-2; Met1-Thr516) and conjugated with PE under optimum conditions, the unreacted PE was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.03%ProClin300
研究背景C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family, and CSF-1/PDGF receptor subfamily. C-Kit has tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumor in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumors and in distinguishing seminomas from embryonal carcinomas. Mutations in the c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
PE
其他可选修饰符
Unconjugated/FITC
可提供抗体种类
3
抗原信息
免疫原
Recombinant Protein: Human c-Kit Protein (TMPY-01935)
抗原种属
Human
研究领域
Cancer Drug Targets, Cardiac Stem Cell Markers, Receptor Tyrosine Kinases (RTKs)
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
运输方式Shipping with blue ice.

计算器

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关键词

CD-117CD 117

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