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Anti-VCAM-1 Antibody (6R700)
还可以产品编号 TMAY-00289
Anti-VCAM-1 Antibody (6R700) 是一种 Rabbit 抗体，靶向 VCAM-1。Anti-VCAM-1 Antibody (6R700) 可用于 FCM。
Anti-VCAM-1 Antibody (6R700)
Anti-VCAM-1 Antibody (6R700)
还可以产品编号 TMAY-00289
Anti-VCAM-1 Antibody (6R700) 是一种 Rabbit 抗体，靶向 VCAM-1。Anti-VCAM-1 Antibody (6R700) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-VCAM-1 Antibody (6R700) is a Rabbit antibody targeting VCAM-1. Anti-VCAM-1 Antibody (6R700) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6R700 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human VCAM1 expression on HUT78 cells.Cells were stained with purified anti-Human VCAM1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human VCAM1 (rh VCAM1; NP_001069.1Met1-Pro697). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human VCAM1 Protein |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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