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别名 抗CLDN6抗体 (AB1-11), AB1-11
Anti-CLDN6 Antibody (AB1-11) 是一种针对 Claudin-6 (CLDN6) 的人源化单克隆抗体。CLDN6 是一种紧密连接蛋白,属于癌胚抗原,在胎儿组织中表达,但在正常成人组织中几乎不表达,而在卵巢癌、生殖细胞肿瘤、胃癌和肺癌等多种实体瘤中高度重现。该抗体特异性结合 CLDN6 的胞外环结构,通过诱导抗体依赖性细胞毒性 (ADCC) 和补体依赖性细胞毒性 (CDC) 作用,发挥强效的抗肿瘤活性。由于其高度的肿瘤特异性,该抗体是开发靶向疗法(如 ADC 或双特异性抗体)的理想候选工具。
Anti-CLDN6 Antibody (AB1-11) 是一种针对 Claudin-6 (CLDN6) 的人源化单克隆抗体。CLDN6 是一种紧密连接蛋白,属于癌胚抗原,在胎儿组织中表达,但在正常成人组织中几乎不表达,而在卵巢癌、生殖细胞肿瘤、胃癌和肺癌等多种实体瘤中高度重现。该抗体特异性结合 CLDN6 的胞外环结构,通过诱导抗体依赖性细胞毒性 (ADCC) 和补体依赖性细胞毒性 (CDC) 作用,发挥强效的抗肿瘤活性。由于其高度的肿瘤特异性,该抗体是开发靶向疗法(如 ADC 或双特异性抗体)的理想候选工具。

| 产品描述 | Anti-CLDN6 Antibody (AB1-11) is a humanized monoclonal antibody targeting Claudin-6 (CLDN6). CLDN6 is a tight junction protein and an oncofetal antigen typically expressed in fetal tissues but virtually absent in normal adult tissues, while frequently re-expressed in various solid tumors such as ovarian cancer, germ cell tumors, gastric cancer, and lung cancer. This antibody specifically binds to the extracellular loops of CLDN6 and exerts potent anti-tumor activity by inducing antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Due to its high tumor specificity, this antibody serves as an ideal tool for developing targeted therapies, including ADCs or bispecific antibodies. |
| 别名 | 抗CLDN6抗体 (AB1-11), AB1-11 |
| 克隆号 | AB1-11 |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG1 |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | CLDN6 |
| 存储 |
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