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Anti-EZH2 Antibody (2I680)
还可以产品编号 TMAH-00408
别名 Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2, EZH 2, ENX-1, Enhancer of zeste homolog 2, EC 2.1.1.43
Anti-EZH2 Antibody (2I680) 是一种抗体，靶向 EZH2。Anti-EZH2 Antibody (2I680) 可用于 ELISA, IHC。
Anti-EZH2 Antibody (2I680)
Anti-EZH2 Antibody (2I680)
还可以产品编号 TMAH-00408 别名 Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2, EZH 2, ENX-1, Enhancer of zeste homolog 2, EC 2.1.1.43
Anti-EZH2 Antibody (2I680) 是一种抗体，靶向 EZH2。Anti-EZH2 Antibody (2I680) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-EZH2 Antibody (2I680) is an antibody targeting EZH2. Anti-EZH2 Antibody (2I680) can be used in ELISA, IHC. |
| 别名 | Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2, EZH 2, ENX-1, Enhancer of zeste homolog 2, EC 2.1.1.43 |
| Ig Type | Rabbit IgG |
| 克隆号 | 2I680 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00408 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human KMT6 / EZH2 |
| 抗原种属 | Human |
| 基因ID | 2146 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Cancer |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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