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Anti-OSMR Antibody (9K249)
还可以产品编号 TMAY-01774
别名 OSMRB, oncostatin M receptor
Anti-OSMR Antibody (9K249) 是一种 Mouse 抗体，靶向 OSMR。Anti-OSMR Antibody (9K249) 可用于 ELISA,ELISA(Det),IP。
Anti-OSMR Antibody (9K249)
Anti-OSMR Antibody (9K249)
还可以产品编号 TMAY-01774 别名 OSMRB, oncostatin M receptor
Anti-OSMR Antibody (9K249) 是一种 Mouse 抗体，靶向 OSMR。Anti-OSMR Antibody (9K249) 可用于 ELISA,ELISA(Det),IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 585 | 5日内发货 | |
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-OSMR Antibody (9K249) is a Mouse antibody targeting OSMR. Anti-OSMR Antibody (9K249) can be used in ELISA,ELISA(Det),IP. |
| 别名 | OSMRB, oncostatin M receptor |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9K249 |
| 交叉反应 | Human |
| 验证活性 | OSMR was immunoprecipitated using: -Lane A:0.5 mg Hela Whole Cell Lysate. -2 µL anti-OSMR mouse monoclonal antibody and 60 μg of Immunomagnetic beads Protein G. -Primary antibody: -Anti-OSMR mouse monoclonal antibody, at 1:100 dilution. -Secondary antibody: -Dylight 800-labeled antibody to Mouse IgG (H+L), at 1:7500 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 111 kDa. -Observed band size: 111 kDa |
| 应用 | ELISA,ELISA(Det),IP |
| 推荐剂量 | ELISA: 1:1000-1:2000; IP: 0.5-2 μL/mg of lysate; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human OSMR / IL31RB (rh OSMR; TMPY-01305; NP_003990.1; Met 1-Met 740). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis of familial cutaneous lichen amyloidosis. PLCA1 is hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human OSMR protein (TMPY-01305) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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