Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anticancer agent 43 是一种有效的抗癌剂,通过 caspase 3, PARP1,Bax 蛋白依赖性途径诱导癌细胞凋亡 (apoptosis)。Anticancer agent 43 能够诱导 DNA 损伤,可用于研究大鼠胶质母细胞瘤 。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 872 | 现货 | ||
10 mg | ¥ 1,390 | 现货 | ||
25 mg | ¥ 2,380 | 现货 | ||
50 mg | ¥ 3,530 | 现货 | ||
100 mg | ¥ 4,930 | 现货 | ||
500 mg | ¥ 9,870 | 现货 |
产品描述 | Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in rats. |
体外活性 | Anticancer agent 43 (compound 3a) exhibits selectivity towards human tumor cells, with an SI50 of 28.94[1]. In HepG2 cells treated with 45 µM for 24 hours, Anticancer agent 43 induces apoptosis through caspase 3, PARP1, and Bax-dependent pathways[1]. However, it has no effect on the transition of G1/S phases in HepG2 cells at the same concentration and time point[1]. Additionally, in various cell lines, including HCT116, MCF-7, HepG2, and Balb/c 3T3 cells, Anticancer agent 43 induces DNA damage at concentrations of 0.7, 45, and 55 µM, as evidenced by tail DNA and Olive Tail Moment (OTM) measurements[1]. |
分子量 | 336.36 |
分子式 | C14H9FN2O3S2 |
CAS No. | 2470015-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (297.30 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.973 mL | 14.865 mL | 29.7301 mL | 74.3251 mL |
5 mM | 0.5946 mL | 2.973 mL | 5.946 mL | 14.865 mL | |
10 mM | 0.2973 mL | 1.4865 mL | 2.973 mL | 7.4325 mL | |
20 mM | 0.1487 mL | 0.7433 mL | 1.4865 mL | 3.7163 mL | |
50 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4865 mL | |
100 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Anticancer agent 43 2470015-35-9 Apoptosis Inhibitor inhibitor inhibit