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Anti-IL-8/CXCL8 Antibody (5K777)
还可以产品编号 TMAY-00250
Anti-IL-8/CXCL8 Antibody (5K777) 是一种 Mouse 抗体，靶向 IL-8/CXCL8。Anti-IL-8/CXCL8 Antibody (5K777) 可用于 ELISA,ELISA(Det)。
Anti-IL-8/CXCL8 Antibody (5K777)
Anti-IL-8/CXCL8 Antibody (5K777)
还可以产品编号 TMAY-00250
Anti-IL-8/CXCL8 Antibody (5K777) 是一种 Mouse 抗体，靶向 IL-8/CXCL8。Anti-IL-8/CXCL8 Antibody (5K777) 可用于 ELISA,ELISA(Det)。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-IL-8/CXCL8 Antibody (5K777) is a Mouse antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (5K777) can be used in ELISA,ELISA(Det). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5K777 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Det) |
| 推荐剂量 | ELISA: 1:1000-1:2000; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-8/Interleukin-8/CXCL8 (rh IL-8/Interleukin-8/CXCL8; TMPY-04726; NP_000575.1; Ser28-Ser99). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/HRP |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human IL-8/Interleukin-8/CXCL8 Protein (TMPY-04726) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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