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Anti-ITGAV Antibody (8H884)

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产品编号 TMAH-00648
别名 VTNR, VNRA, Vitronectin receptor subunit alpha, Vitronectin receptor, MSK8, Integrin alpha-V, CD antigen CD51

Anti-ITGAV Antibody (8H884) 是一种抗体，靶向 ITGAV。Anti-ITGAV Antibody (8H884) 可用于 ELISA, IF, FCM。

Anti-ITGAV Antibody (8H884)

Anti-ITGAV Antibody (8H884)

Rating icon 还可以
产品编号 TMAH-00648 别名 VTNR, VNRA, Vitronectin receptor subunit alpha, Vitronectin receptor, MSK8, Integrin alpha-V, CD antigen CD51

Anti-ITGAV Antibody (8H884) 是一种抗体，靶向 ITGAV。Anti-ITGAV Antibody (8H884) 可用于 ELISA, IF, FCM。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,195
5日内发货
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生物活性
产品描述
Anti-ITGAV Antibody (8H884) is an antibody targeting ITGAV. Anti-ITGAV Antibody (8H884) can be used in ELISA, IF, FCM.
别名VTNR, VNRA, Vitronectin receptor subunit alpha, Vitronectin receptor, MSK8, Integrin alpha-V, CD antigen CD51
Ig Type
Mouse IgG2a
克隆号
8H884
交叉反应
Human, Mouse
验证活性
1. Immunofluorescence staining of NIH/3T3 cell with TMAH-00648 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
2. Overlay Peak curve showing MCF7 cells surface stained with TMAH-00648 (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,011 events was performed.
应用
ELISA, IF, FCM
推荐剂量
IF:1:20-1:200; FCM:1:20-1:200.
抗体种类
Monoclonal
亚细胞定位Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 act as a receptor for CD40LG. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human ITGAV Protein
抗原种属
Human
基因ID
3685
Uniprot ID
研究领域
Cancer, Cardiovascular, Microbiology, Signal transduction, Stem cells
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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